With the advent of next-generation sequencing technology, rare variant association analysis is increasingly being conducted to identify genetic variants associated with complex traits.In recent years, significant effort has been devoted to develop powerful statistical methods to test such associations for population-based designs.However, there has
Abstract Background Ischemic stroke in white matter of the brain induces not only demyelination, but also neuroinflammation.Peripheral T lymphocytes, especially regulatory T cells (Tregs), are known to infiltrate into ischemic brain and play a crucial role in modulation of inflammatory response there.We previously reported that transplantation of v
Abstract Background Early microbial exposure is associate with protective allergic asthma.We have previously demonstrated that Streptococcus pneumoniae aminopeptidase N (PepN), one of the pneumococcal components, inhibits ovalbumin (OVA) -induced airway inflammation in murine models of allergic asthma, but the underlying mechanism was incompletely
Water meters of different types and sizes are used to monitor Alarm Communicator and bill the water supply.Although the water is of drinking water quality, its chemo-physical properties often adversely affect the measuring behaviour of a meter after a while.There is thus the risk that they no longer meet legal requirements and may no longer be used